Graham denounced the decision as a "catastrophe in the making" and said Trump's decision would encourage the return of ISIS mercenaries.
"This decision would force the people of northern and eastern Syria to align with the Syrian regime and Iran," Graham said
Graham stressed that this would destroy Turkey's relationship with the US Congress, and would be a stain on the honor of the United States by abandoning the population of northern and eastern Syria.
"If this plan goes ahead, we will oppose this decision in the Senate and we will ask for it to be annulled," Graham said.
"We expect to have strong bipartisan support," he added.
"I don't know all the details of President Trump's decision in northern Syria, and I will call Secretary of State Pompeo, if press reports are accurate, this is a catastrophe in the making," he concluded.